Two scientific research fruits of scientists from Zhejiang University got published on an international top journal

2019-10-29 11:17:20 source: Zhejiang News


On October 25 of Beijing time, two scientific research fruits of the research team led by Guo Jiangtao from the Medical School and the team headed by Professor Dante Neculai from the department of basic medicine of Zhejiang University were published on Science, an international top journal.


Researches of Zhejiang University published in Science

"Seeing clearly" the structure of potassium-chlorine co-transport protein offers new inspiration to the treatment of epilepsy


1571975010286_5db26f62159bb82b0d3a0c6c.jpeg


On the cytomembrane, there is a type of proteins called positive ion-chloridion co-transport protein, which can effectively regulate the stability of ions such as potassium, sodium and chlorine in the cells. However, all the time, due to lack of accurate structural information, the working mechanism of this type of proteins is still hardly understood.


Recently, the research team led by Guo Jiangtao with the Medical School of Zhejiang University has studied and interpreted the 2.9-angstrom HR cryo-EM structure of a member of the type of proteins--humna's potassium-chlorine co-transport protein KCC1, revealed the binding site of potassium ions and chloridion and proposed a model of the potassium-chlorine co-transport mechanism, which will provide a new perspective for the treatment of related diseases and designing of drugs.


On October 25, the research was published on Science, an international top journal. Dr. Liu Si of the Medical School, Dr. Chang Shenghai of the Cryo-EM Center and Master Han Binming of the department of physics of Zhejiang University are the first co-authors of the paper.


The HR cryo-EM structure of KCC1 will help the designing of drugs for KCC in the next step and provide help to the treatment of diseases such as epilepsy. The reviewer of the paper argued, "This work has unveiled an exciting structure of human’s translocator."


Scholars of Zhejiang University have published a paper on Science to reveal the secrets behind two important proteins


NOD1 and NOD2 are important identification receptors of congenital immunity of IBD (inflammatory bowel disease). As the identification receptors, they take respective positions. One works on the city walls, and the other works in the city walls.


Recently, the team headed by Professor Dante Neculai from the department of basic medicine of Zhejiang University has studied and discovered that the two important receptor proteins NOD1 and NOD2 of NLR family can activate palmitoylation modification under the action of ZDHHC5, a transferase, thus dredging the signal channel of bacterial inflammation. This discovery has effectively linked up scientific mechanism and clinical issues, which may bring important values in terms of diagnosis and treatment in the future.


1571975010461_5db26f62159bb82b0d3a0c71.jpeg



This research was published on Science, an international top journal, on October 25, whose first co-authors include Lu Yan, a 2015 doctoral candidate and Zheng Yuping, a 2017 doctoral candidate, with the department of basic medicine of Zhejiang University, post-doctoral candidate Étienne Coyaud with the Research Center of Canada Princess Margaret Cancer Research Institute and Zhang Chao, a lecturer with the department of basic medicine of Zhejiang University.


The anonymous expert said that the paper showed that the researches of the authors were very strict and serious and elaborated the main ideas in multiple lines. The research and discovery is highly innovative, which will receive wide attention from the field of pathogenic immune response.




Executive Editor: Ke Ye

Translation: Wenjin Chen

read more

11276385 Two scientific research fruits of scientists from Zhejiang University got published on an international top journal public html

On October 25 of Beijing time, two scientific research fruits of the research team led by Guo Jiangtao from the Medical School and the team headed by Professor Dante Neculai from the department of basic medicine of Zhejiang University were published on Science, an international top journal.


Researches of Zhejiang University published in Science

"Seeing clearly" the structure of potassium-chlorine co-transport protein offers new inspiration to the treatment of epilepsy


1571975010286_5db26f62159bb82b0d3a0c6c.jpeg


On the cytomembrane, there is a type of proteins called positive ion-chloridion co-transport protein, which can effectively regulate the stability of ions such as potassium, sodium and chlorine in the cells. However, all the time, due to lack of accurate structural information, the working mechanism of this type of proteins is still hardly understood.


Recently, the research team led by Guo Jiangtao with the Medical School of Zhejiang University has studied and interpreted the 2.9-angstrom HR cryo-EM structure of a member of the type of proteins--humna's potassium-chlorine co-transport protein KCC1, revealed the binding site of potassium ions and chloridion and proposed a model of the potassium-chlorine co-transport mechanism, which will provide a new perspective for the treatment of related diseases and designing of drugs.


On October 25, the research was published on Science, an international top journal. Dr. Liu Si of the Medical School, Dr. Chang Shenghai of the Cryo-EM Center and Master Han Binming of the department of physics of Zhejiang University are the first co-authors of the paper.


The HR cryo-EM structure of KCC1 will help the designing of drugs for KCC in the next step and provide help to the treatment of diseases such as epilepsy. The reviewer of the paper argued, "This work has unveiled an exciting structure of human’s translocator."


Scholars of Zhejiang University have published a paper on Science to reveal the secrets behind two important proteins


NOD1 and NOD2 are important identification receptors of congenital immunity of IBD (inflammatory bowel disease). As the identification receptors, they take respective positions. One works on the city walls, and the other works in the city walls.


Recently, the team headed by Professor Dante Neculai from the department of basic medicine of Zhejiang University has studied and discovered that the two important receptor proteins NOD1 and NOD2 of NLR family can activate palmitoylation modification under the action of ZDHHC5, a transferase, thus dredging the signal channel of bacterial inflammation. This discovery has effectively linked up scientific mechanism and clinical issues, which may bring important values in terms of diagnosis and treatment in the future.


1571975010461_5db26f62159bb82b0d3a0c71.jpeg



This research was published on Science, an international top journal, on October 25, whose first co-authors include Lu Yan, a 2015 doctoral candidate and Zheng Yuping, a 2017 doctoral candidate, with the department of basic medicine of Zhejiang University, post-doctoral candidate Étienne Coyaud with the Research Center of Canada Princess Margaret Cancer Research Institute and Zhang Chao, a lecturer with the department of basic medicine of Zhejiang University.


The anonymous expert said that the paper showed that the researches of the authors were very strict and serious and elaborated the main ideas in multiple lines. The research and discovery is highly innovative, which will receive wide attention from the field of pathogenic immune response.




Executive Editor: Ke Ye

Translation: Wenjin Chen

]]>
Zhejiang;protein;published;department;Science;medicine;structure;basic;important;journal